She was a guest host Tuesday morning, after winning an online contest where viewers, nationwide, voted for her.
Janelle showed a video of herself looking back at her childhood and journalism career. Regis asked Janelle about her future plans:
"You're doing very well with your career, what is your next step? When do you dump Spencer Christian?" asked Regis.
"Spencer and I are partners in crime," said Janelle.
"Oh now, you're network bound, big thing. Diane Sawyer can't hold on forever," said Regis.
"Thank you, but San Francisco is my home," said Janelle.
Janelle gave Regis a signed 49ers Joe Montana jersey as a gift and later interviewed actor James Spader.
You can always watch Janelle and her co-host Spencer Christian each weekday at 3 p.m. on The View from the Bay. The show is also streamed live everyday on viewfromthebay.com.