They left San Francisco after sweeping the A's in the Bay Bridge Series.
Giants' rookie Brandon Belt will fulfill his dream by starting at first base. He hit his way onto the team during spring training.
"I have been dreaming about this my entire life. It's finally come true now. I feel like I'm about to have a heart attack and I want to cry all at the same time. I don't know what to think right now, but I'm just going to have fun with it," said Belt.
"It's got to be a dream come true. As a kid growing up, I don't know what he was like as a kid, but I would imagine it was his dream to play Major League Baseball and he is going to get to start on Opening Day," said Giants catcher Buster Posey.
Bay Area fans can watch the game on the JumboTron at AT&T Park. Doors open at 4 p.m. for those who purchase tickets with proceeds going to The Guardsmen Campership and Scholarship Programs, which support at risk students in grades K-12.
Tickets can be purchased starting at $45 for General Admission from www.GuardsmenSeasonOpener.com. VIP Donor tickets are also available for $80 and include a hosted bar with beer and wine.
The World Series trophy will be on display and there will be a raffle for Giants memorabilia and other prizes during the 7th inning stretch. All attendees will receive free tours of the stadium, dugouts and visitor's clubhouse.