The victim, a 44-year-old San Jose man, was riding across Tully Road between La Ragione and Galveston avenues when he was struck by a four-door Ford traveling east on Tully Road around 6:50 p.m.
He was taken to Regional Medical Center of San Jose with injuries that were potentially life-threatening, police said.
The driver of the Ford remained at the scene after the accident and has been cooperating with investigators.
There is no indication that the driver was under the influence of alcohol or drugs, according to police.
Motorists, bicyclists and pedestrians are reminded to be aware of their surroundings and to take into consideration the recent time change, which has made commuting hours darker.
Anyone with information about the collision is asked to call the San Jose Police Department's traffic investigations unit at (408) 277-4654. Those who wish to remain anonymous may call Silicon Valley Crime Stoppers at (408) 947-STOP (7867) or visit svcrimestoppers.org.