As of 11:50 a.m., the CHP said traffic in both directions on Highway 92 was being diverted because of the crash, which is being investigated by the San Mateo County Sheriff's Office.
A sheriff's spokesman was not immediately available for comment.
The CHP issued a Sig-alert at 11:06 a.m., and it is expected to be in effect until about 12:30 p.m.