Whetstone was killed and a second man was injured when someone fired at them at about 2:40 a.m. Sunday near Fourth and Mission streets, police said.
Whetstone was pronounced dead at the scene, and the second victim was taken to a hospital with life-threatening injuries, according to police.
"No arrests had been made in the case as of this morning," police Officer Gordon Shyy said.
Anyone with information about the killing is asked to call the Police Department's anonymous tip line at (415) 575-4444 or send a tip by text message to TIP411.