Officers responded to a report of a shooting in a home in the 2200 block of Branyan Way at about 10 p.m., police said.
When officers arrived at the scene, they found two men suffering from gunshot wounds. Both victims - a 24-year-old Oakley resident and 20-year-old Suisun resident - were transported to a hospital, according to police.
The 24-year-old, whose name has not yet been released, was later pronounced dead. The condition of the 20-year-old was unknown, police said.
No arrests were made in the shooting. No further details were immediately available.
Anyone with information about the incident is asked to call Antioch police at (925) 779-6894.