Marchers started on Powell Street made their way through the Castro, then to the Mission District. It was a smaller crowd than the one in Oakland, but a large gathering nonetheless.
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Shock has turned into anger for many -- an emotional crowd took to San Francisco streets to send president-elect Trump a message.
"We're not going to make life easy for him. Just like he didn't make life easy for Obama. Same kind of situation we got here," said protester Rafael Picazo.
"Basically, come together and unite in this country and say that we're against hatred, against homophobia, bigotry, sexism," said Rebecca Mattos, a protester.
PHOTOS: Protests spark in Bay Area after 2016 election
At Harvey Milk Plaza in the Castro, a quieter demonstration of people gathered with candles and found comfort in solidarity.
"To see that people, there's actually people who still live here and they haven't all moved to Canada," said Jayson McCauliff.
"I came up from the station this morning and there was a woman giving out free hugs and it was a glimmer of hope in all of this," said San Francisco resident Erik Leve.
Other disappointed voters turned to their faith. At Grace Cathedral, the church offered a service for healing and unity after a stream of parishioners stopped for prayer throughout the day.
"I think that Christianity can be misunderstood, but for me it's a message of unity and not one of disunity and that's what's hard about what's happening," said San Francisco resident Sarah Behrens.
It was an election outcome many San Francisco voters are struggling to accept.
Click here for full coverage of the 2016 election.