The fire was reported around 6:35 a.m. in the 600 block of Silverado Trail and was contained about half an hour later, Cal Fire said.
Twohey said the fire was confined to the living room area of the vacant, single-story, 1,800-square foot home. The cause is under investigation but the fire started near an entertainment system, he said.
The blaze caused about $250,000 in damage to the structure and destroyed about $150,000 worth of contents, Twohey said. There was smoke damage throughout the house.
Firefighters from St. Helena, Angwin, Deer Park, Rutherford, Yountville and Cal Fire also responded to the blaze.
Silverado Trail was closed between Pope Street and Taplin Road until around 9 a.m., Cal Fire spokeswoman Joanne Davis said.
