The crash occurred shortly after 12:20 a.m. in the tunnel, which connects Oakland to Alameda, police Lt. Sean Lynch said.
Police had tried to pull over the suspect in a traffic stop but he fled, driving over a dirt lot and heading the wrong way into the Webster Street Tube, where he crashed head-on into two cars bound for Alameda, Lynch said.
The driver of the first car suffered "significant" injuries and was taken to a hospital. Lynch did not know the victim's condition this morning.
No other serious injuries were reported, he said.
The driver and a male passenger in his car tried to run away after the crash but were quickly apprehended, Lynch said.
Lynch said the suspects are refusing to cooperate with police. Their names have not been released.
The crash shut down the tunnel for hours. It was reopened at about 7:40 a.m. once the crash debris was cleared from the roadway, Lynch said.