The department's Special Entry and Apprehension Team served a search warrant at 1610 Michael Drive at about 7 p.m.
Officers discovered about half a pound of methamphetamine and an ounce of cocaine inside the home, police said.
They also seized six weapons, including an Uzi and a MAC-11, both with silencers, along with two ballistic helmets and $3,000 in cash, police said.
Police arrested the homeowners, James Neitte, 49, and Theresa Neitte, 48, on suspicion of selling drugs, possession of a machine gun, possession of a firearm with a silencer, and possessing controlled substances while armed with a loaded firearm, police said.
They were taken to the Martinez Detention Facility.