The CHP was alerted that a man was walking along the shoulder of southbound Highway 280 just south of John Daly Boulevard at about 5:50 a.m., CHP Officer Shawn Chase said.
The victim, later identified as 53-year-old Walter Barrett, of Oakland, apparently tried to walk across the highway and was struck by a gray 2009 Toyota Corolla.
Barrett crashed through the windshield of the Toyota and died from his injuries, Chase said.
The driver of the Toyota drove away afterward and had not been located as of this morning, Chase said.
Anyone who might have witnessed the collision or has information about the driver is asked to contact CHP Officer Cathy Bowling at (415) 557-1094.