The home invasion robbery was reported at 1:58 p.m. at the home in the 2000 block of 45th Avenue.
The 31-year-old victim had left the door to his house open, and two suspects entered, pulled out a gun, and ordered the man to lie on the floor, according to police.
The suspects then ransacked the house, taking an iPod and guitar before fleeing. They had not been found as of today, police said.
The victim was not injured during the robbery.
Anyone with information about the case is encouraged to call the Police Department's anonymous tip line at (415) 575-4444 or send a tip by text message to TIP411.