The Channel One said that the suspects were plotting to kill Putin in Moscow immediately after the March 4 presidential election, in which he is all but certain to reclaim the presidency.
The station said the suspects had been arrested in Ukraine's Black Sea port city of Odessa, but didn't give any further details.
Putin's spokesman Dmitry Peskov confirmed the report to the ITAR-Tass news agency, but refused to make any further comment.
Russian and Ukrainian special services wouldn't comment on the report.
Earlier this month, the Ukrainian Security Service said it detained three Russian citizens on terrorist charges in Odessa on Feb. 4. It wasn't immediately clear whether those suspects were linked to the anti-Putin plot.
The Ukrainian Security Service said the suspects were arrested following an accidental explosion that happened while they were trying to manufacture explosives at a rented apartment.