KFDM-TV reports that the collision happened around 8 a.m. Thursday on I-10 near Beaumont, about 80 miles east of Houston.
Texas Department of Public Safety trooper Stephanie Davis says two people in an SUV died after the crash, but declined to provide details. She says at least 100 cars and trucks crashed in extremely dense fog. Officials at Acadian Ambulance service tell KFDM that at least 51 people have been taken to area hospitals and that at least eight are critically hurt.
I-10 remains shutdown in eastbound lanes. Westbound lanes have reopened.