The deadly collision occurred near the Tom Lantos Tunnels just south of Pacifica around 3:25 a.m. and reportedly involved two cars, according to the CHP.
Emergency responders pronounced one person dead at the scene. No other injuries have been reported.
An investigation and cleanup at the scene of the crash blocked the roadway in both directions until a short time after 8:30 a.m., according to the CHP.
The cause of the crash remains under investigation and the name of the deceased person has not been released.