The crash was reported shortly before 9 a.m. on westbound Highway 580 near Hopyard Road and initially blocked all but one of the westbound lanes, CHP Officer Adan Garcia said.
One of the big-rigs overturned and its fuel tank ruptured, spilling between 75 to 100 gallons of diesel fuel onto to the roadway, Garcia said.
Ambulances responded to the scene but Garcia said there weren't any major injuries and no one was transported to a hospital.
