Officers responded to reports of a crash involving a pedestrian on Highway 85 north of Snell Avenue at around 4:15 a.m., the CHP said.
The teenager had been trying to cross from the right shoulder to the center divide when he was fatally struck by a 2012 BMW, according to the CHP.
The 36-year-old driver was not injured and stopped at the scene, the CHP said.
It was not immediately known why the boy was trying to cross the roadway.
The incident remains under investigation by the CHP.