The victim, Daniel Dennard, was shot to death at the intersection of Bayshore Boulevard and Industrial Street while he was stopped at a red light around 7:20 p.m., police Sgt. Wilfred Williams said.
The shooter fled in a black, two-door Honda Accord or Acura with tinted windows, police said.
Anyone with information about the shooting or the suspect is urged to contact the San Francisco Police Department's Homicide Section at (415) 553-1145, or call the Confidential Tip Line at (415) 575-4444.