Up to 80 percent of CHP officers will be monitoring roadways throughout the state during the maximum enforcement period, which begins 6 p.m. today and ends at midnight Monday.
Officers will specifically look for motorists speeding, driving under the influence and not wearing their seatbelts.
According to the CHP, the number of fatal crashes during holidays has generally declined despite an increase in the population of the state.
"We believe this is due not only to safety improvements in the vehicles, but also the added public awareness combined with increased enforcement," CHP Deputy Commissioner Skip Carter said in a statement. "As a result, thousands of lives have been saved over the past 60 years."
In addition to the highway patrol's maximum enforcement period, Bay Area law enforcement agencies will be participating in the Avoid anti-DUI campaign between today and Monday.
Avoid spokeswoman Jan Ford said 138 local law enforcement agencies will be partake in the crackdown in Napa, Sonoma, Solano, Marin, Contra Costa, Alameda, San Francisco, San Mateo and Santa Clara counties.