The crash, reported at about 7:45 a.m., closed the roadway until about 11:30 a.m., CHP Officer Kevin Kroncke said.
The driver of a Nissan Z coupe was traveling south on the narrow, twisted highway and was "going a bit too fast," CHP Officer Shawn Chase said.
The Nissan crossed over the center line and crashed into another car head-on, killing the driver, Chase said.
The driver of the Nissan was taken to San Francisco General Hospital. A third car was also involved in the crash but that driver was not injured.