Detectives believe the gardens are funded by major drug trafficking organizations in Mexico and are operated by Mexican nationals, Lt. Gary Faulkner said.
No arrests were made but narcotics detectives found sophisticated camps near the grow sites, Faulkner said.
On Monday, drug enforcement teams found 12,173 plants in gardens in Cole Canyon and Miller Canyon, Faulkner said.
On Tuesday, three gardens containing 43,414 plants were found in Mix Canyon and Gates Canyon, Faulkner said.
The plants were hoisted away by helicopter to a command post and were later destroyed at an undisclosed location, Faulkner said.
The California Multi-Jurisdictional Methamphetamine Enforcement Team, Solano Narcotics Enforcement Team and California Department of Justice's Campaign Against Marijuana Planting participated in the eradication of the plants.