Northbound Interstate 880 between Hegenberger Road and 98th Avenue will be closed overnight from 1 a.m. to 6 a.m.
Drivers will follow a detour that will get them back on the freeway at 66th Avenue.
The closure is part of construction for a shuttle bridge that will eventually link BART and the Oakland Airport.
The project is expected to be completed by the end of the year. The airport connecter will be open for service in late 2014.