"We're not going to ask one guy to cover him," Ryan said. "Yeah, he'd have to look like King Kong."
Ryan said there could be as many as three players assigned to Gronkowski on some snaps when the Bills host the Patriots on Sunday.
"He's hard to cover," Ryan said. "He's going to make catches. You just don't want him to go off on you for three touchdowns or whatever. He's as good of a tight end as there is in the league. He's pretty good."
It's not the first time this week that Ryan has made a movie reference when speaking about Gronkowski. On Monday, Ryan called Gronkowski a "hell of an actor" when praising the Patriots' star tight end.
In his past three games against Ryan-coached defenses, Gronkowski has caught 19 passes for 213 yards and one touchdown.
"Obviously you don't just put one guy on this guy. That's been proven," Ryan said later Wednesday in a conference call with reporters covering the Patriots. "I will say this, it's better to put one guy on him than nobody on him. We'll try to have somebody on him, at least."
ESPN.com's Mike Reiss contributed to this report.
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