There's never been a medical explanation for why Vujicic was born without arms or legs. He tried to kill himself when he was 10-years-old but by his late teens he had turned that depression into inspiration for himself, and others.
"I have no arms or legs but I am very thankful I have this little chicken drumstick here," the 27-year-old said during one of his speeches to children and adults all around the world through his non-profit 'Life without Limbs.'
He is coming to San Francisco this weekend at the request of Reverend Amos Brown and other spiritual leaders. They hope his message of overcoming limitations will help heal communities torn by crime and social problems.
"We refuse to stoop to hate, violence, to division and meanness, but we are going to work to bolster community, love, respect and civility," Brown said.
ABC7 spoke with Vujicic via Skype, and he says his message is about turning obstacles into opportunity, and being thankful for what we do have.
"Well it's just a great, great perspective, reality check if you want to say, of all of us knowing that no matter what we have in life, we have a choice to be angry for what we don't have or things that we don't understand, or be thankful for what we do have," he said.
Vujicic says his journey is based in his Christian faith, but he believes the principles can be applied by anyone.