The robbery was reported at about 10:55 p.m. near the intersection of Anderson Street and Eugenia Avenue.
The 28-year-old victim was getting out of her car when two men approached her, according to police.
One pulled out a handgun and demanded the woman's property and she complied, handing over her purse, an iPod, a cellphone and cash, police said.
The men ran away and had not been found as of Thursday morning.
The victim was not injured in the robbery.
Anyone with information on the case is asked to call the Police Department's anonymous tip line at (415) 575-4444 or send a tip by text message to TIP411.