The collision occurred at about 12:20 a.m. Saturday.
Police spokesman Officer Eric Chiang said the victim, a 24-year-old man, was riding west on 25th Street when a gray sedan traveling east on 25th turned north onto Bartlett Street and struck him.
The sedan did not stop, and continued down Bartlett, Chiang said. The bicyclist was hospitalized with life-threatening injuries.
No arrests have been made. An update on the bicyclist's condition was not immediately available today.