The big-rig reportedly flipped onto its driver's side at about 12:10 p.m., completely blocking the ramp that connects westbound Highway 92 to southbound Highway 101, CHP Officer Kevin Bartlett said.
The truck's driver was not injured in the crash, and no other vehicles were involved, Bartlett said.
It appears the driver failed to negotiate a curve in the ramp, causing a truckload of smashed vehicles to topple onto the roadway, Bartlett said.
The roadway reopened at 3:52 p.m., according to the CHP.