The incident was reported at 2 p.m. at the movie theater on the second floor of the mall at 925 Blossom Hill Road, fire spokesman Mike Van Elgort said.
Cleaning products in the bathroom apparently combined to create a dangerous vapor, causing authorities to evacuate the entire second floor of the mall, Van Elgort said.
A moviegoer was transported to a hospital for minor respiratory injuries from the vapor, he said.
Santa Clara County and San Jose hazardous materials teams were at the scene as of shortly after 3 p.m. to investigate and eliminate the hazard, Van Elgort said.