The truck crashed just south of the state Highway 238 interchange a few minutes after noon, CHP Officer Scott Cakebread said.
A Sig-alert was issued at 12:22 p.m. and remained in effect until about 2:50 p.m. when the road reopened, Cakebread said.
No one was injured in the accident, but Cakebread said the big-rig's fuel tanks were damaged and leaked diesel onto the road.