The fire was reported at 2:07 a.m. at 161 Noe St. Firefighters responded and extinguished the blaze by 2:45 a.m.
Fire spokeswoman Mindy Talmadge said the blaze caused about $110,000 in damage to the building and $48,000 to property inside.
No injuries were reported in the fire, which displaced two residents, fire officials said. The cause remains under investigation.