She's given few speeches since the election, so a big spotlight will be shined on the former presidential candidate.
RELATED: Join ABC7 at the 2017 PBWC Conference in SF
Clinton will be the closing keynote speaker at the 2017 Professional BusinessWomen of California Conference.
The former Democratic presidential candidate has not revealed what exactly she'll say to the crowd, but this will be the first time she will be in San Francisco since a pre-election trip in October.
This annual event empowers women through inspiring speakers, informative seminars, mentoring and networking opportunities.
In addition to Clinton, attendees will hear from hidden figures actress Taraji P. Henson and actress-activist Rosario Dawson.
PBWC was founded 28 years ago by Peninsula Congresswoman Jackie Speier, who spoke with Cheryl Jennings on Beyond the Headlines. "I wanted to create a place for women to come together, and to network and to do professional development," she said.
Kristen Sze moderated a panel last year, and will be serving as conference host along with ABC7 News' Cheryl Jennings and Ama Daetz.
All 5,000 tickets have sold out and there is a waitlist. But if you're not able to go, ABC7 has you covered! We'll bring you coverage on Twitter, Facebook, Instagram, Snapchat, and on abc7news.com all day at the conference. Follow us for live updates throughout the day.
Click here for full coverage on the Professional BusinessWomen of California Conference.
PHOTOS: ABC7 News at the 2016 PBWC Conference in SF