The fire was reported west of Yountville in the 6000 block of Dry Creek Road around 4:15 p.m.
PHOTOS: Dry Creek brush fire threatens homes, wineries in Napa
The fire scorched at least 53 acres and burned dangerously close to homes. Crews running dozer and dropping fire retardant managed to contain the fire by 25 percent.
A witness told ABC7 News that the fire broke out on Mount Veeder Road. Smoke could be seen from downtown Napa.
A viewer shared the photo below with ABC7 News, which was taken near Silverado Trail.
Deputies said an evacuation center has been set up at the Crosswalk Community Church at 2590 First St. in Napa.
There are no reports of injury at this time.
CAL FIRE is investigating the cause of the fire.
Bay City News contributed to this story.