The Fighting Irish coach required treatment after the game, including an ice wrap he was seen wearing as he hobbled through the stadium tunnel.
"The whole second half, I'm limping around," Brey told reporters with a laugh after the game. "I played hurt. I played hurt."
Brey said he felt the injury as he was jumping around with 15 minutes to play and initially thought it was to his Achilles tendon.
Notre Dame advanced to play North Carolina in the Elite Eight with the 61-56 win.
"It's unbelievable," Brey said. "But I think I'm going to be ready Sunday."
Brey on back-to-back trips to the Elite Eight
Notre Dame coach Mike Brey tells Andy Katz about the calf injury he endured during the Irish's Sweet 16 win over Wisconsin and about his coaching strategy that pushed his team into the Elite Eight during the final seconds.