The female driver of the car that was hit was transported to a local trauma center for treatment. The big-rig's driver suffered only minor injuries, according to police.
Fremont police received multiple 911 calls reporting a crash on westbound Auto Mall Parkway shortly after 5:15 a.m., police Sgt. Jeff Swadener said.
The westbound lanes are closed between Fremont and Grimmer boulevards, Swadener said.
Motorists traveling on southbound Interstate Highway 680 connecting to Interstate Highway 880 are advised stay on the freeway and avoid the area.
Swadener said around 7 a.m. that at least one lane of eastbound Auto Mall Parkway was also shut down.