He scored in the 21st, 48th, 74th and 76th minutes for a 4-0 lead to give him 148 goals in 338 matches. Landon Donovan, who played for San Jose from 2001-04 before finishing his career with the Los Angeles Galaxy, had 145 goals in 340 games.
The Earthquakes (4-6-2) have three wins and two ties in the past six matches.
- Carlisle: How Wondo broke MLS' all-time goals record
Chicago (4-5-4), which got a goal by Aleksandar Katai in the 83rd minute, entered with three consecutive shutouts but Wondolowski shredded the Fire for his first four-goal game of his career. He had not scored this season in his previous 10 matches (four starts).
On his first goal to tie the record, he used his outstretched right leg to nudge a pass from Shea Salinas past goalkeeper David Ousted.
The goal ended the Fire's shutout streak at 298 minutes.
He broke the record when Cristian Espinoza sent a free kick into the box. Ousted had the shot slip out of his hands on the rainy afternoon, and Wondolowski was there to poke the ball in with his left foot from 4 yards.
Wondolowski made it 3-0 by finishing a run Espinoza started. Espinoza was pulled down outside the penalty area by Marcelo but play continued and Wondolowski cleaned up the loose ball.
He completed his scoring with a slotted ball shot from the top of the box after a pass from Jackson Yueill.
Wondolowski was substituted to a standing ovation in the first minute of stoppage time as a congratulatory message from Donovan was shown on the video board.
The Fire hosts New York City FC on May 26. The Earthquakes play at Toronto FC on May 26.
Wondolowski breaks Donovan's MLS goals record in San Jose rout
San Jose's Chris Wondolowski has broken Landon Donovan's all-time MLS goals record with the first two of four strikes in a 4-1 win over the Chicago Fire.
Wondolowski breaks MLS all-time scoring record
Major League Soccer: Chris Wondolowski (48') San Jose 2-0 Chicago Fire
Wondolowski ties MLS all-time scoring record with 145th goal
Major League Soccer (Chris Wondolowski (21') San Jose 1-0 Chicago Fire