The incident occurred at about 1 a.m. at Elephant Pharmacy at 1607 Shattuck Ave., according to police.
The pharmacy's surveillance cameras captured the three men arriving in a 1990s model 2-door white sedan and gaining entry into the store by prying open the back door, police said.
The suspects took several hundred pills from the store, according to police.
Anyone who may have information about the crime is urged to call the Berkeley Police Department Property Crimes Detail at (510) 981-5737 or the non-emergency dispatch line at (510) 981-5900. Callers wishing to remain anonymous can also call the Bay Area Crime Stoppers tip line at (800) 222-TIPS.