Two lanes are blocked this morning after the accident was reported at 5:29 a.m. near Vallecitos Road. An alert was issued at 6:19 a.m., according to the CHP.
An ambulance was initially called to the scene but no injuries have been reported, a CHP officer said.
Crews are working to move the big-rig, but lanes are expected to be affected by the accident for hours, the CHP said.