"Castro knows how to party, and Castro knows how to do Halloween," said Masood Samereie.
Samereie is the President of the Castro Merchants Association.
RELATED: Bay Area health officials announce COVID guidelines for safe, fun Halloween night
He says after a rough 18 months for local businesses, Halloween is a chance to get things back to some sense of normal.
"We need the business, we need the people to come out, but as I said, responsibly and safely," Samereie said.
But that invitation comes with some caveats.
VIDEO: Santa Rosa's Blind Scream Haunted House offers scary good fun spanning 20,000 square feet
In years past, the neighborhood has been more cautious around Halloween with those who don't live nearby. Especially in the aftermath of 2006's celebration, which ended with violence and several shootings.
"We have been working with the San Francisco Police Department and other city agencies for anything that comes up with this event," said Samereie.
With precautions in place, the Castro is once again ready to open up to the world, sharing a key part of its rich history and culture.
RELATED: 2,191-pound mega gourd wins World Championship Pumpkin Weigh-Off in Half Moon Bay
"The community counts on certain celebrations like Pride, Halloween is another explosion of our personality and individuality. And it's really a lot of what the Castro is about," said Terry Asten Bennett, the general manager of Cliff's Variety.
And local businesses say, they're ready once again.
"Extremely busy. Maddening busy. You know there's busy and then there's maddening busy. So I think we're going to have a maddening busy time," said restaurant manager, Rocky Misquita.