Gilroy firefighters responded at 2:20 p.m. to the 1700 block of Mantelli Drive after someone reported the explosion.
Mantelli Drive between Rancho Hills Drive and Learnard Way will be closed Monday night, will likely be closed for the Tuesday morning commute and may be closed for several days, police said.
It is still unknown how long the street will be closed while the scene is being processed.
The victim is currently being treated at an area trauma center, officials say.
Gilroy police say the types of explosives on-scene are still undetermined, but it does not appear to be related to a drug lab.
The explosion is being investigated by the Santa Clara County Sheriff's Office bomb squad.
Road Closure - 1700 block of Mantelli Drive do to police activity https://t.co/lfViFxQUg8— Gilroy Police (@GilroyPD) October 13, 2020
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ABC7 News contributed to this report.