A total of 21 people were taken to the hospital after the crash, which happened at about 2 p.m. near Highland Avenue, officials said.
Four passengers suffered major injuries, and none of the injuries were life-threatening, according to authorities.
The bus was transporting a group of women from the Ministerios Llamada Final church in Downey, according to an announcement made by its pastor during its 3 p.m. service.
A hard closure was placed from Highland Avenue to City Creek Ranger Station, according to San Bernardino fire officials.
Officials said the primary hospital for the injured would be Loma Linda University Medical Center.