The two-alarm fire broke out around 11 a.m. at 3740 Sacramento Street.
Two people were also rescued from the fire.
The cause of the fire is under investigation.
Stay with ABC7 News on this developing story
UPDATE 2nd ALARM FIRE 3740 SACRAMENTO 2 RESCUED 1 stable 1 fatality ACTIVE INCIDENT (Presidio Heights, San Francisco) 📲 Live on @CitizenAppSFO https://t.co/6abTEMOYKk
— SAN FRANCISCO FIRE DEPARTMENT MEDIA (@SFFDPIO) July 12, 2020