PHILADELPHIA -- Six San Francisco 49ers left Sunday's game against the Philadelphia Eaglesbecause of injury and did not return, and there are two -- left tackle Joe Staley and free safety Jimmie Ward -- who could be missing extended time.
Staley did not return to the Bay Area with the team after suffering a right eye injury in the second quarter of a 33-10 loss to the Eagles. A source tells ESPN's Adam Schefter that Staley fractured his orbital bone, but expects to play again this season.
Staley suffered a gash under his right eye when he was blocked by Eagles defensive tackle Fletcher Cox as he attempted to tackle Eagles cornerback Jalen Mills, who was returning an interception for a touchdown.
The NFL is reviewing the play by Cox for potential discipline and possible suspension.
Ward, meanwhile, suffered what coach Kyle Shanahan confirmed after the game was a fractured arm. Shanahan was unsure where the fracture was in the arm, though Ward's injury was initially announced as a forearm issue.
Rookie Adrian Colbert replaced Ward at free safety and finished the game.