The total was up from 101 last season and broke the previous Opening Day mark of 110 in 2008.
The commissioner's office has records dating to 1995, when 46 players started the year on the DL. Because of expansion to 30 teams in 1998, MLB says it is virtually certain that the DL total was not higher in a season before its DL records began. Before 2008, the only season in which the opening DL total reached triple digits was 2001 with 104.
Among those on the DL are Detroit pitcher Justin Verlander, Los Angeles Angels outfielder Josh Hamilton, Texas pitcher Yu Darvish, Baltimore catcher Matt Wieters, Philadelphia pitcher Cliff Lee and Los Angeles Dodgers closer Kenley Jansen.
Oakland and Texas started with eight players each on the DL. Minnesota was the only team with none.
Olney on Verlander's DL stint
Buster Olney discusses Detroit's decision to place pitcher Justin Verlander, who has been dealing with a slight triceps strain, on the disabled list.