The limited-edition line features Mrs. Which, Mrs. Who, and Mrs. Whatsit, three "powerful warriors made of stardust" who guide Meg Murry (portrayed in the film by Storm Reed) on a journey across the universe to find her missing father.
The dolls, which are available now for pre-order ahead of their Feb. 23 release, were designed by Carlyle Nuera.
Director Ava DuVernay - who herself was also featured on a Barbie doll in 2015 - posted a photo of the dolls to her social media accounts with a poignant message about representation.
"When Disney makes Barbies of your movie's characters and you just want to stare at them all day in disbelief because you loved Barbies as a girl but never had any like these," she wrote.
When Disney makes Barbies of your movie’s characters and you just want to stare at them all day in disbelief because you loved Barbies as a girl but never had any like these. #WrinkleinTime pic.twitter.com/7PzQsiNoyG— Ava DuVernay (@ava) January 25, 2018
DuVernay has been vocal about her support for diversity in the entertainment industry, pledging last year that the film would have a cast "that looked like you, looked like the real world."
"A Wrinkle in Time" hits theaters in the United States on March 9, 2018.
Editor's note: The Walt Disney Company is the parent company of Walt Disney Studios and this station.