The highway will be closed until 8 a.m. Saturday between Glen Cove Road and Home Acres Avenue.
The same section of the road will again be closed between Saturday at 11 p.m. and Sunday at 9 a.m., on Sunday at 10 p.m. until 6 a.m. Monday and on Monday between midnight until 6 a.m.
The road also will be closed Friday April 11 between 11 p.m. and 8 a.m. Saturday April 12.
Westbound traffic will detour to the Glen Cove Road off ramp, turn right on Glen Cove Road, left on Benicia Road and left onto Lemon Street to the Interstate Highway 780 and Interstate Highway 80 interchange.
Caltrans said motorists should expect delays and take alternate routes. Traffic fines are doubled in construction zones, Caltrans officials said.