Riverside and Temecula were the only other California cities selected by Relocate America, which helps home buyers and sellers access moving destinations.
"Naturally we're pleased to be one of only three California cities selected for this honor," Vacaville Mayor Len Augustine said.
"It's a tribute to our residents, our employees, our businesses, and our community in general. Next year our goal is to make the Top Ten, and I think we can do it," Augustine said.
Steve Nickerson, President and CEO of TrueV New Media which maintains RelocateAmerica.com, said 1,800 cities were nominated in 2009.
Nickerson said Relocate America concentrated on the outlook for future growth and the ability of the communities to rebound from the current economy and housing market.
"We looked at the local government and business leadership in each community as we considered this year's winners. We selected communities with visionary leaders, improving or thriving economies including housing and realization of 'green initiatives'," Nickerson said.
The selection of the top 100 cities is based on interviews with local leaders, feedback from residents, and economic, environmental, education, crime, employment and housing data for the past year.