Firefighters arrived at the fire, located at 190 Boutwell St., at about 10:30 p.m., Lt. Ken Smith said. They controlled the blaze at about 11:40 p.m., according to the dispatcher.
Everyone was evacuated from the home and no injuries were reported, Smith said.
The third alarm was called at 11 p.m.
Smith said this fire was particularly difficult to fight because there is more than the usual amount of debris inside the wood-framed home.