Regardless, this young team is not that far away from success.
"It comes down to finishing football games, and that is the thing that we're not doing," says head coach Mike Singletary.
It's been a troubling trend for this young Niner team. If you take away the blowout by Atlanta, San Francisco's four other losses have come by a total of 17 points.
Sunday's loss was especially painful as four Alex Smith turnovers -- including two interceptions off tipped balls -- led to 24 Titans points.
"It kind of comes with the job, it does. When I go and evaluate my play, you know, I guess really look at what can you control and did you make the right decision, could you have thrown a better ball? Things like that," says Smith. "What could I have done differently? It's hard to tell just walking off the field and just reviewing it in my mind. Obviously, there are some things I'd like to have over."
The honeymoon is now over for coach Singletary. Like any NFL head coach, you lose four in a row and optimism is not enough, but he welcomes the challenge of turning this season around.
"In these moments, this is when I am at my best. In these situations, you just have to rise above," says Singletary.
"We're going to continue to work, we're going to continue to fight as a team. And we still got a lot of football left, and it's not over until we play our last game," says linebacker Patrick Wills.
Their next game is Thursday night at Candlestick against the Chicago Bears.