Officers responded to a report of a man down at the intersection of E. Homestead Road and Pomeroy Avenue at about 1 a.m., according to Santa Clara police.
Arriving officers found a 67-year-old Santa Clara man unconscious and critically injured in the roadway.
Paramedics were not able to revive the victim, and he was pronounced dead at a hospital.
Investigators believe the victim was in a wheelchair crossing E. Homestead Road near Quince Avenue when he was struck by a vehicle traveling west, police said.
The vehicle dragged the man approximately 300 feet to where he was found.
The driver has made no attempt to contact the authorities.
Police are trying to compile a description of the suspect vehicle, which likely has significant damage to its front end and possibly to its windshield.
Police are asking for the public's help in finding the suspect driver. Anyone with information regarding the collision is urged to contact Santa Clara police Investigator Kenia Soto at (408) 615-4764.
Anonymous tips can be given online at www.svcrimestoppers.org.