The victory was costly for the Cardinal, who lost senior receiver Chris Owusu to a concussion in the second quarter after a helmet-to-helmet collision with Beavers cornerback Jordan Poyer. Owusu was taken from the field by ambulance.
Stanford (9-0, 7-0 Pac-12) extended the nation's longest winning streak to 17 games. The Cardinal have not opened 9-0 since 1952.
Redshirt freshman Sean Mannion threw for 252 yards and a touchdown for Oregon State (2-7, 2-4), which is guaranteed a losing season with the defeat. The Beavers' only wins have come against Arizona and Washington State.